There are generally three types of alcoholic beverages: beers, wines, and liquors. Compared to people who never drank, heavy drinkers (who drink more than 50 g ethanol per day), moderate drinkers (who drink 25 to 50 g ethanol per day), and light drinkers (who drink less than 25 g ethanol per day) had ORs for erosive esophagitis of 1.988 (95% CI: 1.120–3.534, P=0.0190), 1.880 (95% CI: 1.015–3.484, P=0.0445), and 1.110 (95% CI: 0.553–2.228, P=0.7688), respectively (Akiyama et al., 2008). Japanese researchers have studied the correlation between different magnitudes of alcohol consumption and RE. Total alcohol consumption has been shown to be significantly associated with GERD. Alcohol consumption has also been shown to be more common in persons suffering from erosive esophagitis compared to individuals with NERD based on a multivariate analysis (OR=2.9, 95% CI: 1.0–8.3) (Lee et al., 2009). ( 2005) concluded that erosive esophagitis was directly related to alcohol consumption (Pearson’s correlation coefficient: 0.091, P=0.01). The association between alcohol and different types of GERD has also been studied. Chronic excessive alcohol abuse has also been shown to be associated with GERD (odds ratio (OR)=2.85, 95% confidence interval (CI): 1.67–4.49) (Wang et al., 2004). The alcohol consumption was (294.2☗3.4) g/week in the symptomatic group and (53.2☑3.4) g/week in the asymptomatic group (Nozu and Komiyama, 2008). Twenty-three patients were asymptomatic and 64 were symptomatic. A cross-sectional survey was performed in 87 patients with esophagitis diagnosed by endoscopy. Many studies have been performed to examine the association between the alcohol consumption and the risk of GERD. However, evidence on the association between GERD and alcohol consumption has been conflicting. So patients with symptomatic GERD are frequently recommended to avoid alcohol consumption or to consume moderate amount of alcohol. In many cases, symptoms of GERD can be controlled after withdrawl of alcoholic beverages. Alcohol consumption may increase symptoms of GERD and cause damage to the esophageal mucosa. Heavy drinking puts people at a high risk for many adverse health events, potentially including GERD. Recommendations for lifestyle modifications are based on the presumption that alcohol, tobacco, certain foods, body position, and obesity contribute to the dysfunction in the body’s defense system of antireflux.Īlcohol is one of the most commonly abused drugs and one of the leading preventable causes of death worldwide (Lopez et al., 2006). Therefore, it has been regarded as a considerable health problem in most of the world. Symptoms of GERD are chronic and can significantly impair quality of life. GERD has two different manifestations, reflux esophagitis (RE) and non-erosive reflux disease (NERD), depending on the presence or absence of esophageal mucosal breaks. GERD is characterized by the sensation of substernal burning caused by abnormal reflux of gastric contents backward up into the esophagus. Gastroesophageal reflux disease, commonly referred to as GERD, is one of the most common disorders, and its incidence and prevalence have increased over the last two decades.